Injectable DNA-derived biostimulators that repair scalp tissue at a cellular level — creating a healthier environment for follicle function and supporting improved hair density.

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30–45 min

Treatment time

Minimal

Discomfort

3–6

Sessions

2–3 months

Early changes

6–12 months

Density effect

About This Treatment

Scalp
Polynucleotides

Scalp polynucleotides apply the same regenerative science used for skin rejuvenation directly to the scalp — using DNA-derived biostimulators to repair scalp tissue, reduce inflammation and create a healthier environment for hair follicles.

PDRN molecules injected into the scalp stimulate fibroblasts and support angiogenesis (new blood vessel formation), improving the vascular supply to hair follicles and reducing the inflammatory processes that contribute to hair thinning. The result is a healthier scalp environment that supports better follicle function and improved hair quality.

At DermaMedica, scalp polynucleotides are most often used as part of a comprehensive hair restoration protocol — combined with PRP for growth factor stimulation and exosomes for cellular signalling.

How It Works

The treatment
process.

Scalp Preparation

The scalp is cleansed and topical anaesthetic applied. The treatment areas are mapped based on your pattern of thinning.

PDRN Injection

Polynucleotide solution is injected using fine needles across the scalp in the thinning areas — delivering biostimulators directly to the follicle level.

Cellular Repair

The PDRN binds to A2A receptors in scalp tissue, reducing inflammation, stimulating fibroblast activity and improving blood supply to follicles — creating conditions for healthier growth.

Conditions Treated & What to Expect

Who it's for & your journey.

Conditions & Concerns Treated

Androgenetic alopecia (male and female pattern hair loss)

Diffuse hair thinning

Scalp inflammation

Telogen effluvium

Combined hair restoration protocols

Scalp health maintenance

Your Treatment Journey

Before

Wash hair the morning of treatment. Avoid blood thinners for 48 hours.

During

Topical anaesthetic applied. Multiple fine injections across the scalp. 30–45 minutes.

After

Mild tenderness for 24–48 hours. Normal hair washing after 24 hours.

Results

Early improvement in hair quality (thickness per strand) from 2–3 months. Density changes over 6–12 months.

Course

3–6 sessions recommended. Maintenance sessions every 6–12 months.

Common Questions

Everything you
need to know.

How do scalp polynucleotides differ from PRP?

PRP delivers growth factors from your own blood to stimulate follicle activity. Polynucleotides repair scalp tissue at a cellular level and reduce inflammation. Both are effective individually — combined, they address different aspects of the hair loss process simultaneously for superior results.

Is it painful?

Topical anaesthetic is applied before treatment. Most patients find it well-tolerated.

How many sessions do I need?

3–6 sessions for an initial course, spaced 3–4 weeks apart. Maintenance sessions every 6–12 months.

Can it be combined with PRP?

Yes — and this is our preferred approach for most patients seeking hair restoration. The combination addresses multiple mechanisms of hair loss simultaneously.

Medical note: All treatments at DermaMedica are administered by, or under the supervision of, GMC-registered doctors. A face-to-face medical consultation is required before treatment. Not suitable during pregnancy or breastfeeding. Full safety information is provided at consultation.

Not Quite Right?

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Every patient is different. If this treatment isn't the right fit, one of these alternatives may be exactly what you need.

Body

Hair Restoration (PRP)

Combine scalp polynucleotides with PRP hair restoration for a comprehensive multi-mechanism approach to hair density improvement.

Learn more →

Skin Quality

Exosomes

Scalp exosome therapy complements polynucleotides by adding cellular signalling molecules alongside cellular repair.

Learn more →

Body

At-Home Blood Testing

Blood testing to identify nutritional deficiencies (ferritin, B12, vitamin D, thyroid) that may be contributing to hair loss.

Learn more →

Still unsure? Our consultation is always free and never high-pressure.

Book a Free Consultation →

Patient Stories

Trusted by thousands.

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"I was incredibly nervous about having filler for the first time, but Dr Ahmed made me feel so at ease. The results are subtle, natural, and exactly what I wanted."

Sophie R. Marlow

"Best clinic in the area. The medical expertise is evident from the moment you walk in. My skin has never looked better after the HydraFacial course."

James M. Beaconsfield

"Professional, clean, and amazing results. They truly listen to your concerns and never push treatments you don’t need. A breath of fresh air."

Elena K. Cookham

Average Patient Score

4.9

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Scalp
Polynucleotides

Scalp
Polynucleotides

The treatment
process.

Who it's for & your journey.

Conditions & Concerns Treated

Your Treatment Journey

Everything you
need to know.

You might also
love these.

Trusted by thousands.

Start your journey.

What brings you in?

Choose a treatment

When suits you?

Your details

Request Received

ScalpPolynucleotides

ScalpPolynucleotides

The treatmentprocess.

Who it's for & your journey.

Conditions & Concerns Treated

Your Treatment Journey

Everything youneed to know.

You might alsolove these.

Trusted by thousands.

Start your journey.

What brings you in?

Choose a treatment

When suits you?

Your details

Request Received

Scalp
Polynucleotides

Scalp
Polynucleotides

The treatment
process.

Everything you
need to know.

You might also
love these.