Polynucleotides Marlow | PDRN Skin Treatment

What Are Polynucleotides?

Repair from within.

Polynucleotides (PDRN — polydeoxyribonucleotide) are purified fragments of DNA derived from salmon or trout. Far from a traditional filler, they work biologically — binding to receptors in your skin cells to activate the body's natural repair and regeneration pathways.

The result is a genuine improvement in skin quality: increased collagen and elastin production, enhanced hydration from within, and a measurable strengthening of the skin barrier. Unlike treatments that simply add volume, polynucleotides make your skin work better.

At DermaMedica, polynucleotides are used as both a standalone treatment and as part of combination protocols — most often paired with Profhilo, microneedling, or exosomes to amplify regenerative results.

Polynucleotide skin treatment consultation

The Science

How polynucleotides
work.

Receptor Binding

PDRN molecules bind to adenosine A2A receptors on your skin cells. This triggers an anti-inflammatory response and activates the cells responsible for tissue repair — fibroblasts, which produce collagen and elastin.

Cellular Regeneration

Activated fibroblasts begin producing new collagen, elastin, and hyaluronic acid — the three structural proteins responsible for firm, hydrated, resilient skin. This is biological regeneration, not volumisation.

Progressive Improvement

Results develop progressively over 4–12 weeks as new tissue is formed. Because the improvement comes from your own skin's biology, it looks entirely natural — and continues to build between sessions.

What We Treat & What to Expect

Ideal candidates & your journey.

Conditions & Concerns Treated

Under-eye hollows, dark circles & shadowing

Skin laxity & loss of firmness

Crepey texture on face, neck & décolletage

Acne scarring & enlarged pores

Skin barrier damage & dryness

Fine lines & early skin ageing

Thinning skin from hormonal changes

Scalp health & hair thinning (when applied to scalp)

Your Treatment Journey

Before

A topical anaesthetic cream is applied 20–30 minutes prior. Avoid blood-thinning supplements for 48 hours beforehand.

During

Fine-needle injections are placed superficially across the treatment area. The procedure takes 30–45 minutes. Most patients find it comfortable throughout.

After

Mild redness or small injection-point bumps may occur for 24–48 hours. Avoid exercise, alcohol and direct sun for 24 hours. SPF 50 is recommended.

Results

Early hydration improvements appear within 2–4 weeks. Full regenerative results — collagen and elastin production — develop over 6–12 weeks.

Longevity

Results from a full course typically last 6–12 months. Maintenance sessions sustain and build on the improvement.

Common Questions

Everything you
need to know.

What conditions can polynucleotides treat?

Polynucleotides are regenerative injectable treatments used to improve skin quality, hydration, elasticity, and overall skin health. They can help treat concerns such as fine lines, dull or dehydrated skin, acne scarring, skin laxity, and delicate areas including under the eyes and neck.

How many sessions will I need?

Most patients benefit from a course of 2–3 treatments, spaced approximately 2–4 weeks apart, depending on the area being treated and the condition of the skin.

When will I see results?

Polynucleotides work gradually to regenerate and repair the skin. Some patients notice improved hydration and skin quality within a few weeks, with continued improvement developing over the following months as collagen production increases.

Is the treatment painful?

Most patients find polynucleotide treatment very manageable. The injections are performed using fine needles, and discomfort is usually mild and short-lived.

What is the downtime after polynucleotides?

Most patients experience minimal downtime. Some may have slight redness or swelling at the injection sites, but this typically resolves within a few hours to a day.

Can polynucleotides be combined with other treatments?

Polynucleotides can be safely combined with other aesthetic treatments to enhance overall skin rejuvenation and repair. They are often used alongside treatments such as anti-wrinkle injections, microneedling, skin boosters, and medical-grade skincare.

Are polynucleotides safe? Who cannot have the treatment?

Polynucleotide treatment is suitable for most adults looking to improve skin texture, hydration, elasticity, and overall skin quality. However, as the product is derived from salmon DNA, it may not be suitable for vegans or those with fish allergies. A thorough consultation will be carried out to ensure the treatment is safe and appropriate for you.

How long do polynucleotide results last?

Results from polynucleotide treatment can last around 6–12 months, depending on the individual, treatment area, and skincare maintenance. A course of treatments followed by maintenance sessions is usually recommended for optimal long-term results.

Polynucleotides
(PDRN)

Repair from within.

How polynucleotides
work.

Ideal candidates & your journey.

Conditions & Concerns Treated

Your Treatment Journey

Everything you
need to know.

You might also
love these.

Trusted by thousands.

Start your journey.

What brings you in?

Choose a treatment

When suits you?

Your details

Request Received

Polynucleotides(PDRN)

Repair from within.

How polynucleotideswork.

Ideal candidates & your journey.

Conditions & Concerns Treated

Your Treatment Journey

Everything youneed to know.

You might alsolove these.

Trusted by thousands.

Start your journey.

What brings you in?

Choose a treatment

When suits you?

Your details

Request Received

Polynucleotides
(PDRN)

How polynucleotides
work.

Everything you
need to know.

You might also
love these.